Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies
The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality a...
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Published in | The Journal of experimental medicine Vol. 217; no. 10 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Rockefeller University Press
05.10.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The outbreak of coronavirus disease 2019 (COVID-19) is an unprecedented global health crisis. Tissue and peripheral blood analysis indicate profound, aberrant myeloid cell activation, cytokine storm, and lymphopenia, with unknown immunopathological mechanisms. Spatiotemporal control of the quality and quantity of the antiviral immune responses involves synchronized cellular and molecular cascades and cross-talk between innate and adaptive immunity. Dysregulated responses in immunity, such as at the stages of immune sensing, alarming, polarization, and resolution, may contribute to disease pathology. Herein, we approach SARS-CoV-2 through an immunomodulatory lens, discussing possible mechanisms of the asynchronized antiviral immune response and proposing potential therapeutic strategies to correct the dysregulation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 T. Zhou and T.T. Su contributed equally to this paper. Disclosures: The authors declare no competing interests exist. |
ISSN: | 0022-1007 1540-9538 |
DOI: | 10.1084/jem.20200674 |