Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

• Published in: The Journal of experimental medicine Vol. 217; no. 8
• Main Authors: Lin, Jeffrey H., Huffman, Austin P., Wattenberg, Max M., Walter, David M., Carpenter, Erica L., Feldser, David M., Beatty, Gregory L., Furth, Emma E., Vonderheide, Robert H.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.08.2020
• Subjects: Aged; Animals; Carcinogenesis - genetics; Carcinogenesis - immunology; Carcinogenesis - pathology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Dendritic Cells - immunology; Dendritic Cells - pathology; Female; Humans; Male; Mice; Middle Aged; Neoplasm Proteins - genetics; Neoplasm Proteins - immunology; Neoplasms, Experimental - genetics; Neoplasms, Experimental - immunology; Neoplasms, Experimental - pathology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Tumor Immunology
• ISSN: 0022-1007; 1540-9538; 1540-9538
• DOI: 10.1084/jem.20190673

Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated secondarily to invasive cancer. Here, we report that cDC1 dysfunction instead develops in the earliest stages of preinvasive pancreatic intraepithelial neoplasia (PanIN) in the KrasLSL-G12D/+ Trp53LSL-R172H/+ Pdx1-C...