The Relationship Between Angiotensin-Converting Enzyme Gene I/D Polymorphism and Psoriasis, Including Psoriasis with Comorbid Hypertension and Diabetes

• Published in: Clinical, cosmetic and investigational dermatology Vol. 17; pp. 2537 - 2543
• Main Authors: Liu, Jiayun, Sun, Rui, Gao, Guomin, Zhang, Mogen, Fan, Huiping, Ma, Xiaonan, Yu, Yanhong, Yuan, Yanmei, Zhang, Lulu, Niu, Changying
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2024; Dove Medical Press
• Subjects: ACE inhibitors; Analysis; angiotensin-converting enzyme; Blood sugar; chinese han ethnic group; Enzymes; Ethylenediaminetetraacetic acid; gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Hypertension; insertion/deletion mutation; Psoriasis; psoriasis vulgaris; Risk factors; Type 2 diabetes; China; insertion/deletion mutation; gene polymorphism; psoriasis vulgaris; Chinese Han ethnic group; angiotensin-converting enzyme
• ISSN: 1178-7015; 1178-7015
• DOI: 10.2147/CCID.S482663

The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and psoriasis remains unclear. This study aims to analyze the association between ACE gene I/D polymorphism and the risk of psoriasis vulgaris in the Chinese Han population and to examine the correlation between ACE gene I/D polymorphism and psoriasis with comorbid hypertension and diabetes. A total of 358 patients with psoriasis vulgaris and 347 age- and sex-matched healthy volunteers from the Chinese Han population were selected. Clinical data, including blood pressure and fasting blood glucose, were collected from the patients. The ACE gene I/D polymorphism was analyzed using polymerase chain reaction (PCR). The association between ACE gene I/D polymorphism and psoriasis vulgaris, as well as comorbid hypertension and diabetes, was analyzed using the Pearson -test. The frequency of the ACE II genotype (OR = 1.84, 95% CI = 1.30, 2.61; < 0.01) and the I allele (OR = 1.51, 95% CI = 1.22, 1.86; < 0.01) was significantly higher in psoriasis patients compared to the control group. Conversely, the frequency of the ACE DD genotype (OR = 0.62, 95% CI = 0.44, 0.87; < 0.01) and the D allele (OR = 0.66, 95% CI = 0.54, 0.82; < 0.01) was significantly lower in psoriasis patients compared to the control group. No statistically significant differences were observed when stratified by blood pressure and blood glucose abnormalities ( > 0.05). The ACE II genotype and I allele are risk factors for psoriasis vulgaris in the Northern Chinese Han population.