Single-cell analyses of circulating tumor cells

Circulating tumor cells （CTCs） are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths, The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has...

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Bibliographic Details
Published inCancer biology & medicine Vol. 12; no. 3; pp. 184 - 192
Main Authors Chen, Xi-Xi, Bai, Fan
Format Journal Article
LanguageEnglish
Published China Biodynamic 0ptical Imaging Center, School of Life Science, Peking University, Beijing 100871, China 01.09.2015
Chinese Anti-Cancer Association
China Anti-Cancer Association
Subjects
Circulating tumor cells (CTCs)
CTCs
metastasis
Review
single cell sequencing
临床应用
单细胞分析
循环
癌症患者
细胞水平
肿瘤发生
肿瘤细胞
metastasis
single cell sequencing
Circulating tumor cells (CTCs)
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Summary:Circulating tumor cells （CTCs） are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths, The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.
Bibliography:Circulating tumor cells （CTCs）; single cell sequencing; metastasis
Circulating tumor cells （CTCs） are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths, The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.
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Correspondence to: Fan Bai
E-mail: fbai@pku.edu.cn
ISSN:2095-3941
2095-3941
DOI:10.7497/j.issn.2095-3941.2015.0056