Gallbladder carcinoma associated with pancreatobiliary reflux

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 40; pp. 6527 - 6530
• Main Authors: Sai, Jin Kan, Suyama, Masafumi, Kubokawa, Yoshihiro, Nobukawa, Bunsei
• Format: Journal Article
• Language: English
• Published: United States Department of Gastroenterology,Juntendo University,2-1-1 Hongo,Bunkyo-ku,Tokyo 113-8421,Japan%Department of Pathology,Juntendo University,2-1-1 Hongo,Bunkyo-ku,Tokyo 113-8421,Japan 28.10.2006; Baishideng Publishing Group Co., Limited
• Subjects: Adult; Aged; Amylases - analysis; Bile Ducts - diagnostic imaging; Bile Ducts - pathology; Bile Reflux - etiology; Bile Reflux - pathology; Carcinoma - complications; Carcinoma - pathology; Cholangiopancreatography, Endoscopic Retrograde; Female; Gallbladder Neoplasms - complications; Gallbladder Neoplasms - pathology; Humans; Male; Middle Aged; Pancreas - diagnostic imaging; Pancreas - pathology; Prospective Studies; Rapid Communication; Ultrasonography; 胆囊癌; Pancreaticobiliary maljunction; Pancreatobiliary reflux; Diagnosis; Amylase; Bile; Gallbladder carcinoma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i40.6527

AIM： To detect the patients with and without pancreaticobiliary maljunction who had pancreatobiliary reflux with extremely high biliary amylase levels. METHODS： Ninety-six patients, who had diffuse thickness （〉 3 mm） of the gallbladder wall and were suspected of having a pancreaticobiliary maljunction on ultrasonography, were prospectively subjected to endoscopic retrograde cholangiopancreatography, and bile in the common bile duct was sampled. Among them, patients, who had extremely high biliary amylase levels （〉10000 IU/L）, underwent cholecystectomy, and the clinicopathological findings of those patients with and without pancreaticobiliary maljunction were examined. RESULTS： Seventeen patients had biliary amylase levels in the common bile duct above 10000 IU/L, including 11 with pancreaticobiliary maljunction and 6 without pancreaticobiliary maljunction. The occurrence of gallbladder carcinoma was 45.5% （5/11） in patients with pancreaticobiliary maljunction, and 50% （3/6） in those without pancreaticobiliary maljunction. CONCLUSION： Pancreatobiliary reflux with extremely high biliary amylase levels and associated gallbladder carcinoma could be identified in patients with and without pancreaticobiliary maljunction, and those patients might be detected by ultrasonography and bile sampling.