Modeling of Neurodegenerative Diseases: 'Step by Step' and 'Network' Organization of the Complexes of Model Systems

• Published in: International journal of molecular sciences Vol. 24; no. 1; p. 604
• Main Authors: Pasko, Viacheslav Igorevich, Churkina, Aleksandra Sergeevna, Shakhov, Anton Sergeevich, Kotlobay, Anatoly Alexeevich, Alieva, Irina Borisovna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 29.12.2022; MDPI AG
• Subjects: disease modeling; model organisms; neurodegenerative diseases; organoid models; proteinopathies; Review; neurodegenerative diseases; model organisms; organoid models; proteinopathies; disease modeling
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24010604

Neurodegenerative diseases have acquired the status of one of the leading causes of death in developed countries, which requires creating new model systems capable of accurately reproducing the mechanisms underlying these pathologies. Here we analyzed modern model systems and their contribution to the solution of unexplored manifestations of neuropathological processes. Each model has unique properties that make it the optimal tool for modeling certain aspects of neurodegenerative disorders. We concluded that to optimize research, it is necessary to combine models into complexes that include organisms and artificial systems of different organizational levels. Such complexes can be organized in two ways. The first method can be described as "step by step", where each model for studying a certain characteristic is a separate step that allows using the information obtained in the modeling process for the gradual study of increasingly complex processes in subsequent models. The second way is a 'network' approach. Studies are carried out with several types of models simultaneously, and experiments with each specific type are adjusted in conformity with the data obtained from other models. In our opinion, the 'network' approach to combining individual model systems seems more promising for fundamental biology as well as diagnostics and therapy.