Expanding the antimalarial toolkit: Targeting host-parasite interactions

Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 213; no. 2; pp. 143 - 153
Main Authors Langhorne, Jean, Duffy, Patrick E
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 08.02.2016
Subjects
Animals
Antimalarials - pharmacology
Cytokines - immunology
Drug Discovery
Erythrocytes - parasitology
Host-Parasite Interactions - drug effects
Host-Parasite Interactions - immunology
Host-Parasite Interactions - physiology
Humans
Inflammation - prevention & control
Malaria - parasitology
Malaria - prevention & control
Malaria - therapy
Malaria Vaccines - pharmacology
Plasmodium - drug effects
Plasmodium - growth & development
Plasmodium - physiology
Reviews
T-Lymphocytes - immunology
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Summary:Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20151677