Oxygen management in mechanically ventilated patients: A multicenter prospective observational study

• Published in: Journal of critical care Vol. 46; pp. 1 - 5
• Main Authors: Egi, Moritoki, Kataoka, Jun, Ito, Takashi, Nishida, Osamu, Yasuda, Hideto, Okamaoto, Hiroshi, Shimoyama, Akira, Izawa, Masayo, Matsumoto, Shinsaku, Furushima, Nana, Yamashita, Shigeki, Takada, Koji, Ohtsuka, Masahide, Fujisaki, Noritomo, Shime, Nobuaki, Inagaki, Nobuhiro, Taira, Yasuhiko, Yatabe, Tomoaki, Nitta, Kenichi, Yokoyama, Takeshi, Kushimoto, Shigeki, Tokunaga, Kentaro, Doi, Matsuyuki, Masuda, Takahiro, Miki, Yasuo, Matsuda, Kenichi, Asaga, Takehiko, Hazama, Keita, Matsuyama, Hiroki, Nishimura, Masaji, Mizobuchi, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018; Elsevier Limited
• Subjects: Airway management; Arterial oxygen; Fraction of inspired oxygen; Hyperoxemia; Hyperoxia; Intensive care; Mechanical ventilation; Mortality; Multicenter; Observational studies; Oxygen therapy; Patients; Prospective; Ventilators; Japan; FIO2; MV; IQR; Arterial oxygen; Multicenter; Fraction of inspired oxygen; Prospective; PaO2; SaO2; ICUs; Mechanical ventilation; APACHE; Hyperoxemia
• ISSN: 0883-9441; 1557-8615
• DOI: 10.1016/j.jcrc.2018.03.024

To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). In this multicenter prospective observational study, we included adult patients required MV for >48h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from commencement of MV until the 7th day of MV in the ICU. We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2, PaO2 and SaO2 were 0.40, 96mmHg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90mmHg and SaO2 of 97%. PaO2 was ≥100mmHg during 47.2% of the study period and was ≥130mmHg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was ≥130mmHg or SaO2 was ≥99% with a FIO2 of 0.5 or greater. When FIO2 was <0.5, however, FIO2 was less likely decreased regardless of the value of PaO2 and SaO2. In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected. •This is multicentre prospective study to observe the oxygen management in ventilated patients.•Hyperoxemia was common as PaO2 was ≥100mmHg during 47.2% of the study period.•Hyperoxemia was not corrected as FIO2 was less likely decreased when FIO2 was <0.5.