A single institution’s experience with minimally invasive surgery for ovarian cancer, and a systematic meta-analysis of the literature

• Published in: International journal of clinical oncology Vol. 28; no. 6; pp. 794 - 803
• Main Authors: Kamei, Yuji, Kobayashi, Eiji, Nakatani, Eiji, Shiomi, Mayu, Sawada, Masaaki, Kakuda, Mamoru, Toda, Aska, Nakagawa, Satoshi, Hiramatsu, Kosuke, Kinose, Yasuto, Takiuchi, Tsuyoshi, Miyoshi, Ai, Kodama, Michiko, Hashimoto, Kae, Kimura, Toshihiro, Ueda, Yutaka, Sawada, Kenjiro, Kimura, Tadashi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.06.2023; Springer Nature B.V
• Subjects: Aorta; Cancer Research; Carcinoma, Ovarian Epithelial - surgery; Clinical trials; Feasibility studies; Female; Humans; Laparoscopy; Laparoscopy - methods; Laparotomy; Laparotomy - methods; Lymph nodes; Medicine; Medicine & Public Health; Meta-analysis; Minimally Invasive Surgical Procedures - methods; Oncology; Original; Original Article; Ovarian cancer; Ovarian Neoplasms - pathology; Patients; Retrospective Studies; Surgery; Surgical Oncology; Urinary tract; Minimally invasive surgery; Laparoscopy; Laparotomy; Ovarian cancer
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-023-02320-2

Background This study assesses the feasibility of minimally invasive surgery (MIS) for well-selected epithelial ovarian cancer (EOC) patients. Methods We performed a review of data prospectively collected from a single center from 2017 to 2022. Only patients with histologically confirmed EOC, with a tumor diameter of less than 10 cm, were eligible. We also performed a meta-analysis of similar studies comparing the outcomes of laparoscopy and laparotomy. We used MINORS (Methodological Index for Non-Randomized Studies) to assess the risk of bias and calculated the odds ratio or mean difference. Results Eighteen patients were included; 13 in re-staging group, four in PDS group, and one in IDS group. All achieved complete cytoreduction. One case was converted to laparotomy. The median number of removed pelvic lymph nodes was 25 (range 16–34), and 32 (range 19–44) for para-aortic nodes. There were two (15.4%) intraoperative urinary tract injuries. The median follow-up was 35 months (range 1–53). Recurrence was observed in one case (7.7%). Thirteen articles for early-stage ovarian cancer were included in our meta-analysis. Analysis of the pooled results found that MIS had a higher frequency of spillage (OR, 2.15; 95% CI 1.27–3.64). No differences were observed in recurrence, complications, or up-staging. Conclusions Our experience supports the possibility of conducting MIS for EOC in well-selected patients. Except for spillage, our meta-analysis findings are consistent with previous reports, the majority of which were also retrospective. Ultimately, randomized clinical trials will be needed to authenticate the safety.