Comparative Content of Neuron-Specific Enolase in Human Blood Serum and Seminal Plasma

• Published in: Bulletin of experimental biology and medicine Vol. 173; no. 3; pp. 298 - 301
• Main Authors: Sosnin, D. Yu, Gal’kovich, K. R., Khovaeva, Ya. B., Gil’manov, A. Zh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2022; Springer; Springer Nature B.V
• Subjects: Age; Biological products; Biomarkers; Biomedical and Life Sciences; Biomedicine; Blood; Cell Biology; Enzymes; Fertility; Internal Medicine; Laboratory Medicine; Neurons; Pathology; Phosphopyruvate hydratase; Plasma; Semen; Sperm; Tumors; semen; seminal plasma; neuron-specific enolase; blood serum; ejaculate
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05537-9

We studied the content of neuron-specific enolase (NSE) in 69 paired samples of blood serum and seminal plasma from men with azoospermia ( n =11) and oligoastenozoospermia ( n =10) and from men with fertile ejaculate ( n =48). NSE concentration was determined by ELISA (Vector-Best kit). The median concentration and the interquartile range of the NSE content in seminal plasma were 65.7 (47.9; 83.4) ng/ml and 24.33 times ( р <0.000001) exceeded those for blood serum 2.7 (1.45; 4.0) ng/ml. There were no differences in the content of NSE between the groups for both seminal plasma and blood serum. The content of NSE in seminal plasma did not correlate with the content of NSE in blood serum, and also did not depend on the content of spermatozoa. A weak negative correlation ( r =-0.341; p =0.0057) was found between the age of the examinees and the level of NSE in seminal plasma, but not in blood serum.