Endogenous Matrix-Derived Inhibitors of Angiogenesis

Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors...

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Bibliographic Details
Published inPharmaceuticals Vol. 3; no. 10; pp. 3021 - 3039
Main Authors Sund, Malin, Nyberg, Pia, Eikesdal, Hans Petter
Format Journal Article Book Review
LanguageEnglish
Published Basel MDPI AG 01.10.2010
MDPI
Subjects
angiogenesis
biomarker
cancer
collagen
extracellular matrix
Review
therapy
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Summary:Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph3103021