Reporting and methodological quality of clinical trials on exercise therapy for Parkinson's disease

• Published in: Parkinsonism & related disorders Vol. 69; pp. 150 - 156
• Main Authors: Silva, Cláudia M., Travessa, André M., Bouça-Machado, Raquel, Caldeira, Daniel, Ferreira, Joaquim J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019
• Subjects: Clinical trials; Exercise; Parkinson's disease; Physical activity; Registries; Treatment; Clinical trials; Registries; Exercise; Parkinson's disease; Treatment; Physical activity
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2019.11.011

Exercise therapy is becoming extremely relevant as a new efficacious intervention in multiple medical fields. Although several clinical trials have reported benefits of exercise therapy for Parkinson's disease (PD), recommendations and prescriptions for its use in clinical practice remain limited. To evaluate the methodological quality and publication rate of clinical trials on exercise therapy for PD. We analyzed all clinical trials assessing exercise therapy for PD registered in the WHO International Clinical Trials Registry Platform and the ClinicalTrials.gov registries, from 2000 to 2017. We evaluated the methodological quality of trials using the Cochrane Risk of Bias criteria. A total of 236 clinical trials were identified. Only 70 (29.7%) trials reported their findings, and 61 (25.8%) had results published in scientific journals. Most trials had an unclear risk of bias concerning incomplete and selective outcome reporting and lacked data on the randomization process, allocation concealment, blinding of participants and personnel, and outcomes assessors. Aerobic capacity was the most frequent type of exercise intervention. Although a large number of trials on exercise are registered in international portals, the quality of reporting remains suboptimal and only a quarter of trials have their results published in scientific journals. These two factors, in addition to the heterogeneity of the interventions tested and the unsatisfactory reported methodological quality of most trials, compromise the interpretation of study results. Therefore, higher quality clinical trials reports are needed to establish exercise as part of the PD armamentarium. •A significant number of trials on exercise for PD's treatment registered in international portals has no public results or is not published in indexed journals.•The publication rate is low, especially comparing to pharmacological interventions and considering the amount of registered trials.•The methodological quality of study reports is unsatisfactory.•There's a high heterogeneity of interventions and outcomes.