CUTANEOUS MUCORMYCOSIS SECONDARY TO PENETRATIVE TRAUMA

Abstract Introduction Mucormycosis is a rare but serious sequelae of penetrating trauma [1–5] . In spite of aggressive management, mortality remains high due to dissemination of infection. We completed a review of literature to determine the most optimal treatment of cutaneous mucormycosis which occ...

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Bibliographic Details
Published inInjury Vol. 47; no. 7; pp. 1383 - 1387
Main Authors Zahoor, Bilal, Kent, Stephen, Wall, Daryl
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.07.2016
Subjects
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Australia
Combined Modality Therapy
Debridement - methods
Diagnosis
Humans
Management
Mucormycosis
Mucormycosis - complications
Mucormycosis - microbiology
Mucormycosis - mortality
Mucormycosis - therapy
Negative-Pressure Wound Therapy
Orthopedics
Trauma
Treatment
Treatment Outcome
Wound Healing
Wounds, Penetrating - complications
Wounds, Penetrating - microbiology
Wounds, Penetrating - therapy
trauma
treatment
diagnosis
management
mucormycosis
Mucormycosis
Treatment
Management
Diagnosis
Trauma
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Summary:Abstract Introduction Mucormycosis is a rare but serious sequelae of penetrating trauma [1–5] . In spite of aggressive management, mortality remains high due to dissemination of infection. We completed a review of literature to determine the most optimal treatment of cutaneous mucormycosis which occurs secondary to penetrating trauma. Methods We completed a review regarding the management of mucormycosis in trauma patients. We selected a total of 36 reports, of which 18 were case-based, for review. Results Surgical debridement is a primary predictor of improved outcomes in the treatment of mucormycosis [3,6,7] . Anti-fungal therapy, especially lipid soluble formulation of Amphotericin B, is helpful as an adjunct or when surgical debridement has been maximally achieved. Further research is needed to fully evaluate the impact of topical dressings; negative pressure wound therapy is helpful. Conclusion An aggressive and early surgical approach, even at the expense of disfigurement, is necessary to reduce mortality in the setting of cutaneous mucormycosis that results from penetrating trauma [4,8,9] . Anti-fungal therapy and negative pressure wound therapy are formidable adjuncts.
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ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2016.03.011