Dental stem cells for craniofacial tissue engineering

This article focuses on the biological characterization and discussion of the potential application of oral-derived adult stem cells for craniofacial tissue engineering applications. The authors reviewed experimental (in vitro and in vivo) and clinical reports regarding the isolation, characterizati...

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Published inOral surgery, oral medicine, oral pathology and oral radiology Vol. 113; no. 6; pp. 728 - 733
Main Authors Machado, Elsa, DDS, Fernandes, Maria Helena, PhD, Gomes, Pedro de Sousa, DDS, MSc, PhD
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.06.2012
Elsevier
Subjects
Adult Stem Cells
Biological and medical sciences
Bone Regeneration
Dental Pulp - cytology
Dentistry
Humans
Medical sciences
Mesenchymal Stromal Cells - cytology
Odontogenesis
Otorhinolaryngology. Stomatology
Periapical Tissue - cytology
Periodontal Ligament - cytology
Skull - surgery
Surgery
Tissue Engineering
Tooth Germ - cytology
Tooth, Deciduous - cytology
Craniofacial
Tooth
Tissue engineering
Stem cell
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Summary:This article focuses on the biological characterization and discussion of the potential application of oral-derived adult stem cells for craniofacial tissue engineering applications. The authors reviewed experimental (in vitro and in vivo) and clinical reports regarding the isolation, characterization, modulation, and translational clinical application of human precursor cell populations derived from postnatal dental tissues. Five different human dental stem/progenitor cell populations have been isolated and characterized. These postnatal populations present mesenchymal stem cell–like characteristics and enjoy forceful capabilities regarding the differentiation into odontogenic/osteogenic lineages, supporting evidence—in preclinical and clinical trials—for the regeneration of oral/dental tissues.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2212-4403
2212-4411
DOI:10.1016/j.tripleo.2011.05.039