The Effect of Fatty Acids and BSA Purity on Synthesis and Properties of Fluorescent Gold Nanoclusters

Fluorescent gold nanoclusters (AuNCs) are envisaged as a novel type of fluorophores. This work reports on the first comparative study investigating the effect of presence/absence/abundance of fatty acids (namely palmitic acid, PA) or other substances (like glycoproteins and globulins) in the protein...

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Published inNanomaterials (Basel, Switzerland) Vol. 10; no. 2; p. 343
Main Authors Andrýsková, Pavlína, Šišková, Karolína Machalová, Michetschlägerová, Šárka, Jiráková, Klára, Kubala, Martin, Jirák, Daniel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 17.02.2020
MDPI AG
Subjects
au nanocluster
cell viability
fatty acid
palmitic acid
serum albumin
fatty acid
cell viability
serum albumin
palmitic acid
Au nanocluster
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Summary:Fluorescent gold nanoclusters (AuNCs) are envisaged as a novel type of fluorophores. This work reports on the first comparative study investigating the effect of presence/absence/abundance of fatty acids (namely palmitic acid, PA) or other substances (like glycoproteins and globulins) in the protein (bovine serum albumin, BSA) on synthesis and properties of the final AuNCs. The most popular template (BSA) and microwave (MW)-assisted synthesis of AuNCs have been intentionally chosen. Our results clearly demonstrate that the fluorescent characteristics (i.e., fluorescence lifetime and quantum yield) are affected by the fatty acids and/or other substances. Importantly, the as-prepared AuNCs are biocompatible, as determined by Alamar Blue assay performed on Hep G2 cell line.
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ISSN:2079-4991
2079-4991
DOI:10.3390/nano10020343