Ribavirin: Analytical determinations since the origin until today

Ribavirin (RV) (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and...

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Published inJournal of pharmaceutical and biomedical analysis Vol. 45; no. 2; pp. 185 - 193
Main Authors Bosch, M. Espinosa, Sánchez, A.J. Ruiz, Rojas, F. Sánchez, Ojeda, C. Bosch
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 18.10.2007
Elsevier Science
Subjects
Analysis
Analytical, structural and metabolic biochemistry
Antiviral Agents - analysis
Antiviral Agents - chemistry
Antiviral therapy
Biological and medical sciences
Biological samples
Chromatography, High Pressure Liquid
Electrophoresis, Capillary
Fluorometry - methods
Fundamental and applied biological sciences. Psychology
General pharmacology
Luminescent Measurements
Medical sciences
Molecular Structure
Pharmaceutical formulations
Pharmacology. Drug treatments
Purine Nucleosides - analysis
Purine Nucleosides - chemistry
Radioligand Assay
Review
Ribavirin
Ribavirin - analysis
Ribavirin - chemistry
Ribonucleosides - analysis
Ribonucleosides - chemistry
Spectrophotometry - methods
Antiviral therapy
Review
Biological samples
Ribavirin
Pharmaceutical formulations
Treatment
Dosage form
Nucleoside analog
Antiviral
Determination
Quantitative analysis
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Abstract Ribavirin (RV) (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination.
AbstractList Ribavirin (RV) (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination.
Ribavirin (RV) (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination.
Author Sánchez, A.J. Ruiz
Rojas, F. Sánchez
Ojeda, C. Bosch
Bosch, M. Espinosa
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Issue 2
Keywords Antiviral therapy
Review
Biological samples
Ribavirin
Pharmaceutical formulations
Treatment
Dosage form
Nucleoside analog
Antiviral
Determination
Quantitative analysis
Language English
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Snippet Ribavirin (RV) (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To...
Ribavirin (RV) (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To...
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StartPage 185
SubjectTerms Analysis
Analytical, structural and metabolic biochemistry
Antiviral Agents - analysis
Antiviral Agents - chemistry
Antiviral therapy
Biological and medical sciences
Biological samples
Chromatography, High Pressure Liquid
Electrophoresis, Capillary
Fluorometry - methods
Fundamental and applied biological sciences. Psychology
General pharmacology
Luminescent Measurements
Medical sciences
Molecular Structure
Pharmaceutical formulations
Pharmacology. Drug treatments
Purine Nucleosides - analysis
Purine Nucleosides - chemistry
Radioligand Assay
Review
Ribavirin
Ribavirin - analysis
Ribavirin - chemistry
Ribonucleosides - analysis
Ribonucleosides - chemistry
Spectrophotometry - methods
Title Ribavirin: Analytical determinations since the origin until today
URI https://dx.doi.org/10.1016/j.jpba.2007.06.004
https://www.ncbi.nlm.nih.gov/pubmed/17628382
https://search.proquest.com/docview/68371928
Volume 45
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