Ribavirin: Analytical determinations since the origin until today

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 45; no. 2; pp. 185 - 193
• Main Authors: Bosch, M. Espinosa, Sánchez, A.J. Ruiz, Rojas, F. Sánchez, Ojeda, C. Bosch
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 18.10.2007; Elsevier Science
• Subjects: Analysis; Analytical, structural and metabolic biochemistry; Antiviral Agents - analysis; Antiviral Agents - chemistry; Antiviral therapy; Biological and medical sciences; Biological samples; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Fluorometry - methods; Fundamental and applied biological sciences. Psychology; General pharmacology; Luminescent Measurements; Medical sciences; Molecular Structure; Pharmaceutical formulations; Pharmacology. Drug treatments; Purine Nucleosides - analysis; Purine Nucleosides - chemistry; Radioligand Assay; Review; Ribavirin; Ribavirin - analysis; Ribavirin - chemistry; Ribonucleosides - analysis; Ribonucleosides - chemistry; Spectrophotometry - methods; Antiviral therapy; Review; Biological samples; Ribavirin; Pharmaceutical formulations; Treatment; Dosage form; Nucleoside analog; Antiviral; Determination; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/j.jpba.2007.06.004

Ribavirin (RV) (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination.