Plasma Renin and Aldosterone in Adult-Onset Diabetics with Persistent Proteinuria

• Published in: Japanese Journal of Medicine Vol. 20; no. 3; pp. 194 - 201
• Main Authors: SUGIYAMA, Hiromichi, UCHIMURA, Isao, ODAKURA, Tsutomu, MAEZAWA, Hidenori
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.1981
• Subjects: Adult-onset diabetics; Aldosterone - blood; Angiotensin II - pharmacology; Bed Rest; Diabetes Complications; Diabetes Mellitus - blood; Diabetic Nephropathies - blood; Female; Furosemide - pharmacology; Humans; Male; Middle Aged; Non-hypertensive diabetics; Plasma aldosterone; Plasma renin activity; Proteinuria - blood; Proteinuria - etiology; Renin - blood; Renin - metabolism; Renin-Angiotensin System - drug effects; Space life sciences
• ISSN: 0021-5120; 1881-123X
• DOI: 10.2169/internalmedicine1962.20.194

Plasma renin activity (PRA) and plasma aldosterone (PA) were measured under conditions of bed rest and after administration of furosemide and/or angiotensin II to adultonset diabetics and age-matched controls. Seventeen of the diabetics had no proteinuria (non-proteinuria group) while in the other ten subjects, there was a persistent proteinuria, but no hypertension and renal dysfunction (proteinuria group). In the non-proteinuria group, changes in PRAand PA levels during both bed rest time and after the stimulation with furosemide did not significantly differ from findings in the control group. In the proteinuria group, PRA and PA levels were significantly lower than in the other two groups. PA and diastolic pressure respsnses to angiotensin II were slightly increased in diabetics (N.S.). PA responses to furosemide had significant positive correlation with those to angiotensin II. These findings suggest that the renin-aldosterone system responds normally in adultonset diabetics without proteinuria, but shows lower response in diabetics with persistent proteinuria, even without complications of hypertension and a decreased renal function.