Cellular Reprogramming-A Model for Melanoma Cellular Plasticity

• Published in: International journal of molecular sciences Vol. 21; no. 21; p. 8274
• Main Authors: Granados, Karol, Poelchen, Juliane, Novak, Daniel, Utikal, Jochen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 05.11.2020; MDPI AG
• Subjects: Animals; Cell Differentiation - genetics; Cell Line, Tumor; Cell Plasticity - physiology; cellular plasticity; Cellular Reprogramming - physiology; Gene Expression Regulation, Neoplastic; heterogeneity; Humans; Induced Pluripotent Stem Cells - pathology; Induced Pluripotent Stem Cells - physiology; melanoma; Melanoma - genetics; Melanoma - pathology; Models, Biological; Neoplastic Stem Cells - pathology; Neoplastic Stem Cells - physiology; partial reprogramming; Phenotype; phenotype switch; Review; cellular plasticity; melanoma; phenotype switch; heterogeneity; partial reprogramming
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21218274

Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular mechanisms driving this phenotype switch are not yet fully understood. Considering that cellular heterogeneity within the tumor contributes to the high plasticity typically observed in melanoma, it is crucial to generate suitable models to investigate this phenomenon in detail. Here, we discuss the use of complete and partial reprogramming into induced pluripotent cancer (iPC) cells as a tool to obtain new insights into melanoma cellular plasticity. We consider this a relevant topic due to the high plasticity of melanoma cells and its association with a strong resistance to standard anticancer treatments.