Prostatotropic Action of Glycyrrhizic Acid Disodium Salt in Benign Prostatic Hyperplasia Models

• Published in: Bulletin of experimental biology and medicine Vol. 169; no. 1; pp. 114 - 118
• Main Authors: Nizomov, S. A., Sorokina, I. V., Zhukova, N. A., Borisov, S. A., Tolstikova, T. G., Semenov, D. E., Bakarev, M. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2020; Springer; Springer Nature B.V
• Subjects: Analysis; Animal models; Biomedical and Life Sciences; Biomedicine; Cell Biology; Epithelium; Finasteride; Hyperplasia; Hypertrophy; Internal Medicine; Laboratory Medicine; Oral administration; Pathology; Propionic acid; Prostate; Sulpiride; Testosterone; Testosterone propionate; testosterone; morphology; glycyrrhizic acid; benign prostatic hyperplasia; sulpiride
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-020-04836-3

The prostatotropic activity of glycyrrhizic acid disodium salt (Na 2 GA) was studied in the models of benign prostatic hyperplasia (BPH) induced by chronic injection of sulpiride (40 mg/kg intraperitoneally for 8 weeks) or testosterone propionate (20 mg/kg subcutaneously for 4 weeks) in the Wistar rats. The oral administration of Na 2 GA in a dose of 100 mg/kg produced a moderate antiproliferative effect in both BPH models resulting in reduced volume density of prostatic epithelium (in the testosterone model) and increased volume density of the glandular lumen (in both models). The observed prostatotropic effects of Na 2 GA were similar to those of Permixon and finasteride, but they were less pronounced as confirmed by smaller drops in epithelial volume density and epithelial-to-stromal ratio compared to the effects of both reference drugs.