The Role of GSH in Intracellular Iron Trafficking

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 3; p. 1278
Main Authors Hider, Robert, Aviles, Mayra Vera, Chen, Yu-Lin, Latunde-Dada, Gladys Oluyemisi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 28.01.2021
MDPI AG
Subjects
carnosine
cytosol
glutathione
histidine
labile iron
Review
carnosine
cytosol
glutathione
histidine
labile iron
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Summary:Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22031278