Comparing Diagnostic Performance of Short and Long [ 18 F]FDG-PET Acquisition Times in Giant Cell Arteritis

• Published in: Diagnostics (Basel) Vol. 14; no. 1; p. 62
• Main Authors: Nienhuis, Pieter H, van Nieuwland, Marieke, van Praagh, Gijs D, Markusiewicz, Karolina, Colin, Edgar M, van der Geest, Kornelis S M, Wagenaar, Nils, Brouwer, Elisabeth, Alves, Celina, Slart, Riemer H J A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.12.2023; MDPI
• Subjects: Aneurysms; Biopsy; Cameras; diagnostic accuracy; fluorodeoxyglucose; giant cell arteritis; large-vessel vasculitis; Patients; positron emission tomography; Tomography; vascular inflammation; Vein & artery diseases; giant cell arteritis; diagnostic accuracy; intra-observer agreement; inter-observer agreement; large-vessel vasculitis; vascular inflammation; fluorodeoxyglucose; positron emission tomography
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics14010062

(1) Background: In giant cell arteritis (GCA), the assessment of cranial arteries using [ F]fluorodeoxyglucose ([ F]FDG) positron emission tomography (PET) combined with low-dose computed tomography (CT) may be challenging due to low image quality. This study aimed to investigate the effect of prolonged acquisition time on the diagnostic performance of [ F]FDG PET/CT in GCA. (2) Methods: Patients with suspected GCA underwent [ F]FDG-PET imaging with a short acquisition time (SAT) and long acquisition time (LAT). Two nuclear medicine physicians (NMPs) reported the presence or absence of GCA according to the overall image impression (gestalt) and total vascular score (TVS) of the cranial arteries. Inter-observer agreement and intra-observer agreement were assessed. (3) Results: In total, 38 patients were included, of whom 20 were diagnosed with GCA and 18 were without it. Sensitivity and specificity for GCA on SAT scans were 80% and 72%, respectively, for the first NMP, and 55% and 89% for the second NMP. On the LAT scans, these values were 65% and 83%, and 75% and 83%, respectively. When using the TVS, LAT scans showed especially increased specificity (94% for both NMPs). Observer agreement was higher on the LAT scans compared with that on the SAT scan. (4) Conclusions: LAT combined with the use of the TVS may decrease the number of false-positive assessments of [ F]FDG PET/CT. Additionally, LAT and TVS may increase both inter and intra-observer agreement.