Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction
In a process inhibited by the quinoline antimalarial drugs, Plasmodia detoxify heme released during the degradation of hemoglobin by aggregating it into malarial pigment, an insoluble crystalline heme coordination polymer. Synchrotron x-ray powder diffraction patterns for intact desiccated malarial...
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Published in | The Journal of biological chemistry Vol. 272; no. 2; pp. 713 - 716 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
10.01.1997
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Subjects | |
Online Access | Get full text |
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Summary: | In a process inhibited by the quinoline antimalarial drugs, Plasmodia detoxify heme released during the degradation of hemoglobin by aggregating it into malarial pigment, an insoluble crystalline
heme coordination polymer. Synchrotron x-ray powder diffraction patterns for intact desiccated malarial trophozoites and synthetic
β-hematin have been measured; both materials correspond to a single crystalline triclinic lattice with unit cell parameters
a = 12.2176(4), b = 14.7184(5), c = 8.0456(3) Ã
; α = 90.200(2), β = 96.806(3), γ = 97.818(3)° and Z = 2. These results unambiguously demonstrate that hemozoin crystallites are identical to synthetic β-hematin. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0021-9258 1083-351X |
DOI: | 10.1074/jbc.272.2.713 |