The blood–brain barrier in health and disease: Important unanswered questions

The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural...

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Published inThe Journal of experimental medicine Vol. 217; no. 4
Main Authors Profaci, Caterina P., Munji, Roeben N., Pulido, Robert S., Daneman, Richard
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 06.04.2020
Subjects
Neuroinflammation
Neuroscience
Review
Online AccessGet full text

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Abstract The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease. This review will discuss current knowledge and key unanswered questions regarding the blood–brain barrier in health and disease.
AbstractList The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood-brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer's disease. This review will discuss current knowledge and key unanswered questions regarding the blood-brain barrier in health and disease.
The blood vessels of the central nervous system tightly control the movement of ions, molecules, and cells between the blood and tissue. This “blood–brain barrier” is vital for neural homeostasis and protection. This review discusses current knowledge of the blood–brain barrier, emphasizing key unanswered questions. The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease. This review will discuss current knowledge and key unanswered questions regarding the blood–brain barrier in health and disease.
The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood-brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer's disease. This review will discuss current knowledge and key unanswered questions regarding the blood-brain barrier in health and disease.The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This "blood-brain barrier" is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood-brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer's disease. This review will discuss current knowledge and key unanswered questions regarding the blood-brain barrier in health and disease.
Author Pulido, Robert S.
Munji, Roeben N.
Profaci, Caterina P.
Daneman, Richard
AuthorAffiliation 1 Department of Neurosciences, University of California, San Diego, San Diego, CA
2 Department of Pharmacology, University of California, San Diego, San Diego, CA
AuthorAffiliation_xml – name: 2 Department of Pharmacology, University of California, San Diego, San Diego, CA
– name: 1 Department of Neurosciences, University of California, San Diego, San Diego, CA
Author_xml – sequence: 1
  givenname: Caterina P.
  orcidid: 0000-0002-4073-2164
  surname: Profaci
  fullname: Profaci, Caterina P.
– sequence: 2
  givenname: Roeben N.
  orcidid: 0000-0003-1313-8968
  surname: Munji
  fullname: Munji, Roeben N.
– sequence: 3
  givenname: Robert S.
  surname: Pulido
  fullname: Pulido, Robert S.
– sequence: 4
  givenname: Richard
  orcidid: 0000-0002-7749-6353
  surname: Daneman
  fullname: Daneman, Richard
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32211826$$D View this record in MEDLINE/PubMed
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Snippet The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and...
The blood vessels of the central nervous system tightly control the movement of ions, molecules, and cells between the blood and tissue. This “blood–brain...
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SubjectTerms Neuroinflammation
Neuroscience
Review
Title The blood–brain barrier in health and disease: Important unanswered questions
URI https://www.ncbi.nlm.nih.gov/pubmed/32211826
https://www.proquest.com/docview/2383510172
https://pubmed.ncbi.nlm.nih.gov/PMC7144528
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