The blood–brain barrier in health and disease: Important unanswered questions

The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural...

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Published inThe Journal of experimental medicine Vol. 217; no. 4
Main Authors Profaci, Caterina P., Munji, Roeben N., Pulido, Robert S., Daneman, Richard
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 06.04.2020
Subjects
Neuroinflammation
Neuroscience
Review
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Summary:The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease. This review will discuss current knowledge and key unanswered questions regarding the blood–brain barrier in health and disease.
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Disclosures: The authors declare no competing interests exist.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20190062