Brain Changes in the White Matter of the Brain White Matter Changes and Cognitive Functions in Asymptomatic Patients

We analyzed the relationship between white matter hyperintensities in T2-weighted MR-images (according to Fazekas score) and the state of cognitive functions (total MOCA score) in 65 asymptomatic individuals. A relationship between the presence/number of lesions in the deep white matter of the brain...

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Published inBulletin of experimental biology and medicine Vol. 169; no. 5; pp. 630 - 634
Main Authors Berdalin, A. B., Nikogosova, A. K., Gubskiy, I. L., Kovrazhkina, E. A., Gubskiy, L. V., Lelyuk, V. G.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.09.2020
Springer
Springer Nature B.V
Subjects
Arteries
Asymptomatic
Atrophy
Biomedical and Life Sciences
Biomedicine
Blood flow
Brain
Cell Biology
Cognition disorders
Cognitive ability
Internal Medicine
Laboratory Medicine
Magnetic resonance imaging
Pathology
Substantia alba
Vertebrae
Fazekas scale
magnetic resonance imaging
white matter lesions
cognitive dysfunction
MOCA scale
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Summary:We analyzed the relationship between white matter hyperintensities in T2-weighted MR-images (according to Fazekas score) and the state of cognitive functions (total MOCA score) in 65 asymptomatic individuals. A relationship between the presence/number of lesions in the deep white matter of the brain and cognitive status according to the total MOCA score was revealed. The results of cognitive functions assessment also correlated with MRI evaluation of the severity of brain cortex atrophy. The severity of deep white matter lesions according to the Fazekas scale were also associated with end-diastolic blood flow velocities in the middle cerebral, vertebral, and basilar arteries.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04942-2