AKT and DUBs: a bidirectional relationship

The serine/threonine kinase Akt is crucial for cell physiology and can also contribute to pathology if its activation and regulation is disturbed. This kinase phosphorylates several substrates involved in mechanisms that are altered in human disease. AKT is regulated by several post-translational mo...

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Bibliographic Details
Published inCellular & molecular biology letters Vol. 30; no. 1; pp. 77 - 35
Main Authors Serratore, Valentina, Lucibello, Maria, Malanga, Donatella, Viglietto, Giuseppe, De Marco, Carmela
Format Journal Article
LanguageEnglish
Published England BioMed Central 07.07.2025
BMC
Subjects
AKT kinase
AKT protein
Animals
Autophagy
Cell cycle
Cell migration
Cell survival
Deubiquitinases
Deubiquitinating Enzymes - metabolism
Enzymes
Humans
Kinases
Localization
Phosphatase
Phosphorylation
Post-translation
Post-translational modifications
Proteasomes
Protein Processing, Post-Translational
Protein-serine/threonine kinase
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Regulation
Review
Signal Transduction
Transcription factors
Translation
Ubiquitination
Phosphorylation
Post-translational modifications
Deubiquitinases
AKT kinase
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Summary:The serine/threonine kinase Akt is crucial for cell physiology and can also contribute to pathology if its activation and regulation is disturbed. This kinase phosphorylates several substrates involved in mechanisms that are altered in human disease. AKT is regulated by several post-translational modifications (PTMs), including ubiquitination/deubiquitination. Ubiquitination can both target AKT to the proteasome and promote its activation. The interplay with the deubiquitination mechanism plays a crucial role in almost all biological activities of AKT. Information on the mechanisms of AKT deubiquitination and its key players has evolved rapidly in recent years along with the development of potential targeting strategies, although many of them are still unclear. Nevertheless, AKT in turn regulates various deubiquitinases (DUBs), suggesting further targeting strategies for human diseases. In this review, we aim to provide an up-to-date overview of the dual relationship between AKT and DUBs with respect to potential translational aim.
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ISSN:1689-1392
1425-8153
1689-1392
DOI:10.1186/s11658-025-00753-3