Susceptibility of the Bacteroides fragilis group to newer quinolones and other standard anti-anaerobic agents

• Published in: Journal of antimicrobial chemotherapy Vol. 48; no. 1; pp. 127 - 130
• Main Authors: Horn, Ruth, Robson, Hugh G.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2001; Oxford Publishing Limited (England)
• Subjects: Anti-Infective Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteriology; Bacteroides fragilis - drug effects; Biological and medical sciences; Epidemiology; Fluoroquinolones; Fundamental and applied biological sciences. Psychology; Medical sciences; Microbial Sensitivity Tests; Microbiology; Pharmacology. Drug treatments; Human; Nitro compound; Imidazole derivatives; Enzyme; Bacteroides fragilis; β-Lactams; Enzyme inhibitor; β-Lactamase; Epidemiology; In vitro; Macrolide; Biological activity; Bacteroidaceae; Penicillin derivatives; Carbapenem derivatives; Cephalosporin derivatives; Fluoroquinolone derivatives; Sensitivity resistance; Bacteria; Hydrolases; Antibacterial agent; Clinical isolate; Quinolone derivatives
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/48.1.127

The susceptibilities of 200 clinical isolates of the Bacteroides fragilis group to four quinolones (moxifloxacin, clinafloxacin, trovafloxacin and ciprofloxacin) were determined, as well as to cefoxitin, clindamycin, metronidazole, imipenem and ticarcillin–clavulanic acid. The results for the latter five agents were compared with those of a study on 200 isolates done 6 years previously. Clinafloxacin and trovafloxacin were the most active agents tested with MIC90s lower than all other antimicrobials except imipenem. Susceptibility rates for imipenem, ticarcillin– clavulanic and metronidazole continue to be high, although resistant strains are emerging. For ticarcillin–clavulanic acid and metronidazole, MIC90s increased four- to eight-fold for the B. fragilis species between the two study periods.