Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1

A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone mar...

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Published inEJHaem Vol. 2; no. 2; pp. 285 - 290
Main Authors Hagiwara, Shinya, Kusumoto, Shigeru, Ito, Asahi, Masaki, Ayako, Shiraga, Kazuhide, Tachita, Takuto, Hirade, Kentaro, Oiwa, Kana, Suzuki, Tomotaka, Kinoshita, Shiori, Ri, Masaki, Ito, Yasuhiko, Komatsu, Hirokazu, Inagaki, Hiroshi, Iida, Shinsuke
Format Journal Article
LanguageEnglish
Published Hoboken John Wiley and Sons Inc 01.05.2021
Wiley
Subjects
allogeneic transplantation
Case Report
Case Reports
donor cell‐derived leukemia
volunteer unrelated donor
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Summary:A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric RUNX1‐RUNX1T1 (not DEK‐NUP214) fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell‐derived acute myeloid leukemia harboring a chimeric RUNX1‐RUNX1T1 fusion gene.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Report-1
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.169