Genotoxicity of vegetable cooking oils in the Drosophila wing spot test

Seven vegetable oils consumed by humans were tested for genotoxic activity in the Drosophila somatic mutation and recombination test. The oils included five seed oils (sesame, sunflower, wheat germ, flax, and soy oil) and both first‐class extra‐virgin and low‐grade (refined) olive oil. Larvae of the...

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Bibliographic Details
Published inEnvironmental and molecular mutagenesis Vol. 45; no. 1; pp. 90 - 95
Main Authors Rojas-Molina, Mar, Campos-Sánchez, Juan, Analla, Mohamed, Muñoz-Serrano, Andrés, Alonso-Moraga, Ángeles
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 2005
Wiley-Liss
Subjects
Animals
Biological and medical sciences
Drosophila
Drosophila melanogaster
Drosophila melanogaster - drug effects
Drosophila melanogaster - genetics
Flax
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
genotoxicity
Helianthus
Medical sciences
Mutagenicity Tests
Mutagens - toxicity
Olea
Olive Oil
Plant Oils - toxicity
Sesame Oil
somatic mutation
Soybean Oil
Toxicology
Triticum aestivum
vegetable oils
Cooking
Toxicity
Mutagenicity testing
Insecta
Drosophila
Genotoxicity
Vegetable oil
Drosophilidae
Somatic mutation
Toxicology
Arthropoda
Genetics
vegetable oils
Invertebrata
Drosophila melanogaster
Diptera
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Summary:Seven vegetable oils consumed by humans were tested for genotoxic activity in the Drosophila somatic mutation and recombination test. The oils included five seed oils (sesame, sunflower, wheat germ, flax, and soy oil) and both first‐class extra‐virgin and low‐grade (refined) olive oil. Larvae of the standard (STD) and highly bioactive (NORR) crosses of Drosophila melanogaster were fed medium containing 6% and 12% of each of the oils. Flax oil produced the strongest response, while sesame, wheat germ, and soy oil showed some genotoxic activity. Sunflower and the low‐grade olive oil gave inconclusive results, and extra‐virgin olive oil was clearly nongenotoxic. It is argued that the genotoxicity is probably due to the fatty acid composition of the oils, which after peroxidation can form specific DNA‐adducts. Environ. Mol. Mutagen., 2005. © 2004 Wiley‐Liss, Inc.
Bibliography:ark:/67375/WNG-5VBCS75M-2
ArticleID:EM20078
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content type line 23
ObjectType-Article-1
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ISSN:0893-6692
1098-2280
DOI:10.1002/em.20078