Divergent Multistep Continuous Synthetic Transformations of Allylic Alcohol Enabled by Catalysts Immobilized in Ionic Liquid Phases

Two individual catalytic platforms (metal‐ and organo‐catalyzed) based on the use of an ionic liquid phase were successfully integrated for the synthesis of α‐cyano‐amine and cyanohydrin trimethylsilyl ethers from allylic alcohol. The right combination of continuous flow processes enabled access to...

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Published inChemSusChem Vol. 12; no. 8; pp. 1684 - 1691
Main Authors Peris, Edgar, Porcar, Raúl, García‐Álvarez, Joaquín, Burguete, María Isabel, García‐Verdugo, Eduardo, Luis, Santiago V.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 23.04.2019
Subjects
Alcohol
allylic alcohol
Catalysis
Continuous flow
Ethers
ionic liquid
Ionic liquids
Ions
Liquid phases
Solvents
supercritical CO2
ionic liquid
continuous flow
catalysis
supercritical CO2
allylic alcohol
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Summary:Two individual catalytic platforms (metal‐ and organo‐catalyzed) based on the use of an ionic liquid phase were successfully integrated for the synthesis of α‐cyano‐amine and cyanohydrin trimethylsilyl ethers from allylic alcohol. The right combination of continuous flow processes enabled access to the divergent preparation of two alternative and interesting intermediate compounds from the same starting material. Choose your own adventure! Distinct and individual catalytic platforms (metal‐ and organo‐catalyzed) based on the use of ionic liquids have been successfully integrated for the synthesis of α‐cyano‐amine and cyanohydrin trimethylsilyl ethers from allylic alcohol. Two alternative intermediate compounds can be obtained by selecting the appropriate conditions.
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ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.201900107