Noradrenaline does not change the mode of discharge of auditory cortex neurons

The mode of discharge of auditory cortex cells was studied during iontophoretic application of noradrenaline (NA). Only seven of 190 cells showed changes in interspike interval distribution during NA application. A similar conclusion was drawn when the analysis focused on 68 cells classified as burs...

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Bibliographic Details
Published inNeuroreport Vol. 11; no. 1; p. 23
Main Authors Manunta, Y, Edeline, J M
Format Journal Article
LanguageEnglish
Published England 17.01.2000
Subjects
Anesthesia
Animals
Auditory Cortex - cytology
Auditory Cortex - drug effects
Electrophysiology
Iontophoresis
Membrane Potentials - drug effects
Membrane Potentials - physiology
Neurons - drug effects
Norepinephrine - administration & dosage
Norepinephrine - pharmacology
Rats
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Summary:The mode of discharge of auditory cortex cells was studied during iontophoretic application of noradrenaline (NA). Only seven of 190 cells showed changes in interspike interval distribution during NA application. A similar conclusion was drawn when the analysis focused on 68 cells classified as bursting (n = 15), regular spiking (n = 49) or thin spike (n = 4) cells. Only two bursting cells showed changes in their ISI distribution. The effects on the mode of discharge were independent of the effect on the spike rate and were not a function of cortical depth. These results suggest that the changes in firing mode previously described in vitro occur for a limited percentage of cells and/or for cell types not very often recorded in vivo.
ISSN:0959-4965
DOI:10.1097/00001756-200001170-00005