Alterations of neuroreceptors in nasal hyperreactivity

Cholinergic and adrenergic abnormalities have been observed in nasal allergy and may be due to changes in pharmacological characteristics of neuroreceptors. Radioligand receptor binding studies demonstrated no significant changes in affinities or densities of alpha‐adrenoceptors, a decreased number...

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Bibliographic Details
Published inBritish journal of clinical pharmacology Vol. 30; no. S1; pp. 162S - 164S
Main Authors Megen, YJ, Rodrigues de Miranda, JF, Klaassen, AB
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.1990
Blackwell Science
Subjects
Allergic diseases
Biological and medical sciences
Free Communications
Humans
Immunopathology
In Vitro Techniques
Iodine Radioisotopes
Kinetics
Medical sciences
Nasal Mucosa - metabolism
Nasal Mucosa - pathology
Receptors, Adrenergic - metabolism
Receptors, Muscarinic - metabolism
Receptors, Neurotransmitter - metabolism
Respiratory and ent allergic diseases
Respiratory Hypersensitivity - metabolism
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Summary:Cholinergic and adrenergic abnormalities have been observed in nasal allergy and may be due to changes in pharmacological characteristics of neuroreceptors. Radioligand receptor binding studies demonstrated no significant changes in affinities or densities of alpha‐adrenoceptors, a decreased number of beta‐adrenoceptors and a decreased affinity combined with a decreased number of muscarinic acetylcholine receptors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1990.tb05494.x