Semi‐Interpenetrated Hydrogels‐Microfibers Electroactive Assemblies for Release and Real‐Time Monitoring of Drugs

• Published in: Macromolecular bioscience Vol. 20; no. 7; pp. e2000074 - n/a
• Main Authors: Moghimiardekani, Ali, Molina, Brenda G., Enshaei, Hamidreza, del Valle, Luis J., Pérez‐Madrigal, Maria M., Estrany, Francesc, Alemán, Carlos
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2020
• Subjects: Biomaterials; Biomedical materials; biosensors; Conducting polymers; Conduction; Drug delivery; Drug delivery systems; Drugs; Electrical conduction; Electrochemical analysis; Electrochemistry; Glutamic acid; Hydrogels; Levofloxacin; Mechanical properties; Microfibers; Microparticles; Monitoring; Polymers; poly‐γ‐glutamic acid; poly‐ε‐caprolactone; Redox properties; Side effects; Spectroscopy; poly-γ-glutamic acid; biosensors; drug delivery; conducting polymers; poly-ε-caprolactone
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.202000074

Simultaneous drug release and monitoring using a single polymeric platform represents a significant advance in the utilization of biomaterials for therapeutic use. Tracking drug release by real‐time electrochemical detection using the same platform is a simple way to guide the dosage of the drug, improve the desired therapeutic effect, and reduce the adverse side effects. The platform developed in this work takes advantage of the flexibility and loading capacity of hydrogels, the mechanical strength of microfibers, and the capacity of conducting polymers to detect the redox properties of drugs. The engineered platform is prepared by assembling two spin‐coated layers of poly‐γ‐glutamic acid hydrogel, loaded with poly(3,4‐ethylenedioxythiophene) (PEDOT) microparticles, and separated by a electrospun layer of poly‐ε‐caprolactone microfibers. Loaded PEDOT microparticles are used as reaction nuclei for the polymerization of poly(hydroxymethyl‐3,4‐ethylenedioxythiophene) (PHMeDOT), that semi‐interpenetrate the whole three layered system while forming a dense network of electrical conduction paths. After demonstrating its properties, the platform is loaded with levofloxacin and its release monitored externally by UV–vis spectroscopy and in situ by using the PHMeDOT network. In situ real‐time electrochemical monitoring of the drug release from the engineered platform holds great promise for the development of multi‐functional devices for advanced biomedical applications. An electrochemically controlled free‐standing platform for drug delivery and real‐time monitoring of the released drug is presented. The platform consists of two poly‐γ‐glutamic acid hydrogel layers separated by poly‐ε‐caprolactone microfibers, which are all them semi‐intepenetrated with a conducting polymer. After investigating properties of the platform, its performance is examined by monitoring in real‐time the release of previously loaded levofloxacin .