High tidal volume ventilation produces increased lung water in oleic acid-injured rabbit lungs

Repeated lung inflation with very high tidal volumes (VT) is associated with the production of permeability pulmonary edema in animal models using previously normal lungs. We studied the effect of mechanical ventilation, at VT values approaching those used clinically, on lung weight gain (lung water...

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Bibliographic Details
Published inCritical care medicine Vol. 17; no. 9; p. 908
Main Authors Bowton, D L, Kong, D L
Format Journal Article
LanguageEnglish
Published United States 01.09.1989
Subjects
Animals
Body Water - metabolism
Lung - drug effects
Lung - metabolism
Oleic Acid
Oleic Acids - toxicity
Rabbits
Respiration, Artificial
Thromboxane B2 - biosynthesis
Tidal Volume
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Summary:Repeated lung inflation with very high tidal volumes (VT) is associated with the production of permeability pulmonary edema in animal models using previously normal lungs. We studied the effect of mechanical ventilation, at VT values approaching those used clinically, on lung weight gain (lung water) in salt-perfused rabbit lungs diffusely injured by the administration of oleic acid. Lungs ventilated at a VT of 18 ml/kg gained significantly more weight at 30 through 90 min than did lungs ventilated at 6 ml/kg. These differences in weight gain were not associated with differences in the evolution of thromboxane B2 in the perfusate. The impact of VT on lung water and outcome in patients with lung injury deserves further study.
ISSN:0090-3493
1530-0293
DOI:10.1097/00003246-198909000-00014