Nickel-Catalyzed Cross-Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents

Broad scope and good tolerance: An efficient cross‐coupling of aryltrimethylammonium iodide salts with aryl‐, methyl‐, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the CN bond and displays broad substrate scope and good funct...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 50; no. 21; pp. 4901 - 4904
Main Authors Xie, Lan-Gui, Wang, Zhong-Xia
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.05.2011
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Chemistry
Chemistry, Multidisciplinary
cross-coupling
CN activation
homogeneous catalysis
nickel
organozinc reagents
Physical Sciences
Science & Technology
nickel
CARBON-NITROGEN
C-N activation
BOND FORMATION
ALKYL-HALIDES
DIETHYL PHOSPHITE
ANILINE DERIVATIVES
homogeneous catalysis
organozinc reagents
cross-coupling
SELECTIVE SYNTHESIS
EFFICIENT
ARYL CHLORIDES
GRIGNARD-REAGENTS
ALKENYLATION
Online AccessGet full text

Cover

More Information
Summary:Broad scope and good tolerance: An efficient cross‐coupling of aryltrimethylammonium iodide salts with aryl‐, methyl‐, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the CN bond and displays broad substrate scope and good functional group tolerance. NMP=N‐methylpyrrolidine.
Bibliography:istex:5593FD19115AECB9F95CD63145BBB1BE32BECE9C
ArticleID:ANIE201100683
National Basic Research Program of China - No. 2009CB825300
ark:/67375/WNG-DPCXPKL8-N
National Natural Science Foundation of China - No. 20772119
This research was supported by the National Basic Research Program of China (grant no. 2009CB825300) and the National Natural Science Foundation of China (grant no. 20772119).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201100683