Alkali Metal Alkoxides in Noyori‐Type Hydrogenations

This minireview discusses the accelerative role of alkali metal alkoxides in two important catalytic processes: hydrogenation of ketones and esters with Noyori‐type molecular catalysts. Here I offer my perspective on the unique mechanistic aspects of these reactions – a subject that remains controve...

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Bibliographic Details
Published inEuropean journal of inorganic chemistry Vol. 2021; no. 47; pp. 4884 - 4889
Main Author Dub, Pavel A.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 21.12.2021
Wiley Blackwell (John Wiley & Sons)
Subjects
Alkoxides
Amidates
Base effect
Esters
Hydrogenation
Inorganic chemistry
Ketones
Metal–ligand cooperation
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Summary:This minireview discusses the accelerative role of alkali metal alkoxides in two important catalytic processes: hydrogenation of ketones and esters with Noyori‐type molecular catalysts. Here I offer my perspective on the unique mechanistic aspects of these reactions – a subject that remains controversial and often misunderstood. Chemical modification of the catalyst via the formation of the amidate HM−N−Ma+ complexes and/or physical activation of the substrate through C=O…Ma+ non‐covalent interactions are two factors responsible for the rate acceleration in Noyori‐type hydrogenations.
Bibliography:Dedicated to Professor Rinaldo Poli on the occasion of his 65th birthday.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
USDOE
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.202100742