Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery

Recent years have seen an increased interest in the use of ABC triblock terpolymers to bottom‐up assemble multicompartment patchy nanoparticles. Despite these experimental and theoretical efforts, the applications of polymer‐based patchy nanoparticles remain rather limited. One of the major challeng...

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Published inAngewandte Chemie International Edition Vol. 58; no. 22; pp. 7335 - 7340
Main Authors Wong, Chin Ken, Chen, Fan, Walther, Andreas, Stenzel, Martina H.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 27.05.2019
EditionInternational ed. in English
Subjects
Biological activity
colloidal nanoclusters
Drug delivery
Drug delivery systems
FRET
multicompartment micelles
Nanoparticles
Organic chemistry
patchy particles
Sugar
Terpolymers
triblock copolymers
colloidal nanoclusters
multicompartment micelles
FRET
triblock copolymers
patchy particles
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Summary:Recent years have seen an increased interest in the use of ABC triblock terpolymers to bottom‐up assemble multicompartment patchy nanoparticles. Despite these experimental and theoretical efforts, the applications of polymer‐based patchy nanoparticles remain rather limited. One of the major challenges that eclipses their potential is the lack of knowledge to selectively encapsulate cargoes within different compartments that are separated in the nanometer length scale. Here, strategies are reported to segregate two chemically distinct molecules in either the patches or core compartment of patchy nanoparticles that bear a (bioactive) sugar corona. The potential use of these bioactive patchy nanoparticles containing compartmentalized cargoes for simultaneous drug delivery with real‐time release monitoring capabilities is further demonstrated. Easy as ABC: There is increasing interest in ABC triblock terpolymers for the bottom‐up assembly of multicompartment patchy nanoparticles (NPs). Now, two chemically distinct molecules are segregated in either the patches or core compartment of patchy NPs that bear a sugar corona. Bioactive patchy NPs containing compartmentalized cargoes are promising for drug delivery with real‐time release monitoring.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201901880