Testing for immunomodulatory properties of nanoparticles

Immune activation and inflammation can precipitate a variety of diseases. A screening assay for immunomodulatory properties is described. It is based on freshly isolated human peripheral blood mononuclear cells and allows testing for effects of nanoparticles on the human immune system.

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Bibliographic Details
Published inJournal of biomedical nanotechnology Vol. 7; no. 1; p. 11
Main Authors Jenny, Marcel, Schroecksnadel, Sebastian, Fuchs, Dietmar
Format Journal Article
LanguageEnglish
Published United States 01.01.2011
Subjects
Biological Assay - methods
Cells, Cultured
Cytotoxicity Tests, Immunologic - methods
Humans
Immunity, Innate - drug effects
Immunity, Innate - immunology
Immunologic Factors - toxicity
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Materials Testing - methods
Nanoparticles - toxicity
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Summary:Immune activation and inflammation can precipitate a variety of diseases. A screening assay for immunomodulatory properties is described. It is based on freshly isolated human peripheral blood mononuclear cells and allows testing for effects of nanoparticles on the human immune system.
ISSN:1550-7033
DOI:10.1166/jbn.2011.1175