Regulatory RNAs and control of epigenetic mechanisms: expectations for cognition and cognitive dysfunction

The diverse functions of noncoding RNAs (ncRNAs) can influence virtually every aspect of the transcriptional process including epigenetic regulation of genes. In the CNS, regulatory RNA networks and epigenetic mechanisms have broad relevance to gene transcription changes involved in long-term memory...

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Bibliographic Details
Published inEpigenomics Vol. 8; no. 1; pp. 135 - 151
Main Authors Butler, Anderson A, Webb, William M, Lubin, Farah D
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.01.2016
Subjects
Alzheimer Disease - genetics
Alzheimer's disease
Brain
chromatin
Cognition
Cognition & reasoning
Cognition - physiology
Cognitive ability
Deoxyribonucleic acid
DNA
DNA methylation
Enzymes
Epigenesis, Genetic
Epigenetics
Gene expression
Gene loci
Gene regulation
Gene Regulatory Networks
Genomes
Humans
long noncoding RNA
Long term memory
Memory
Mental disorders
MicroRNAs
Nervous system
Neural plasticity
Neurodegenerative diseases
Neurogenesis
neuroplasticity
neuroscience
Proteins
Recruitment
Review
Ribonucleic acid
RNA
RNA polymerase
RNA, Untranslated - genetics
Schizophrenia
Schizophrenia - genetics
short noncoding RNA
Transcription
long noncoding RNA
chromatin
neuroscience
short noncoding RNA
epigenetics
neuroplasticity
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Summary:The diverse functions of noncoding RNAs (ncRNAs) can influence virtually every aspect of the transcriptional process including epigenetic regulation of genes. In the CNS, regulatory RNA networks and epigenetic mechanisms have broad relevance to gene transcription changes involved in long-term memory formation and cognition. Thus, it is becoming increasingly clear that multiple classes of ncRNAs impact neuronal development, neuroplasticity, and cognition. Currently, a large gap exists in our knowledge of how ncRNAs facilitate epigenetic processes, and how this phenomenon affects cognitive function. In this review, we discuss recent findings highlighting a provocative role for ncRNAs including lncRNAs and piRNAs in the control of epigenetic mechanisms involved in cognitive function. Furthermore, we discuss the putative roles for these ncRNAs in cognitive disorders such as schizophrenia and Alzheimer's disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1750-1911
1750-192X
DOI:10.2217/epi.15.79