Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

Covering: up to 2016 Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide sy...

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Published inNatural product reports Vol. 33; no. 1; pp. 1146 - 1165
Main Authors Liu, Joyce, Zhu, Xuejun, Kim, Seong Jong, Zhang, Wenjun
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Actinomyces - chemistry
Amino Acid Sequence
Antimycin A - analogs & derivatives
Antimycin A - chemistry
Antimycin A - isolation & purification
Antimycin A - pharmacology
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Depsipeptides - chemical synthesis
Depsipeptides - chemistry
Depsipeptides - pharmacology
Molecular Structure
Peptide Synthases - metabolism
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Summary:Covering: up to 2016 Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds. This review discusses the isolation, structural variation, biosynthesis, chemical synthesis, and biological activities of antimycin-type depsipeptides.
Bibliography:Xuejun Zhu received her B.S. (2012) in Biochemistry from Nanjing University. She is currently pursuing her Ph.D. in Chemical and Biomolecular Engineering at the University of California, Berkeley. Her research interests include developing methods to label natural products for use with biorthogonal chemistry.
Wenjun Zhang received her B.S. (2002) and M.S. (2004) in Biochemistry from Nanjing University and her Ph.D. (2009) in Chemical Engineering with Yi Tang at the University of California, Los Angeles. After her postdoctoral training with Christopher T. Walsh at Harvard Medical School, she joined the Department of Chemical and Biomolecular Engineering at the University of California, Berkeley in 2011 and is currently an assistant professor and the Charles R. Wilke Endowed Chair in Chemical Engineering. Her research focuses on understanding and engineering the biosynthesis of natural products for applications related to human health and bioenergy.
Joyce Liu received her B.S. (2011) in Chemical Engineering from the California Institute of Technology. She is currently pursuing her Ph.D. in Bioengineering at the University of California, Berkeley. Her research focuses on the biosynthesis and heterologous expression of medicinally active natural products.
Seong Jong Kim received his Ph.D. (2014) in Chemistry from the University of New South Wales, Australia under the guidance of Professor Shelli R. McAlpine. He is currently a postdoctoral researcher at the University of California, Berkeley, where his research focuses on the isolation, characterization, and structure elucidation of natural products and extracellular signaling small molecules. His research interests include drug discovery and the synthesis of natural products.
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ISSN:0265-0568
1460-4752
DOI:10.1039/c6np00004e