Correlation between Dioxin Levels in Adipose Tissue and Estimated Exposure to Agent Orange in South Vietnamese Residents

• Published in: Environmental research Vol. 65; no. 2; pp. 226 - 242
• Main Authors: Verger, P., Cordier, S., Thuy, L.T.B., Bard, D., Dai, L.C., Phiet, P.H., Gonnord, M.F., Abenhaim, L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.05.1994; Elsevier
• Subjects: 2,4,5-Trichlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Adipose Tissue - chemistry; Adult; Aerosols; Aged; Agent Orange; ANALISIS CUANTITATIVO; ANALYSE QUANTITATIVE; Biological and medical sciences; COMPOSE ORGANOCHLORE; COMPUESTO ORGANICO DEL CLORO; Defoliants, Chemical; Dioxins - analysis; Environmental Exposure; Environmental pollutants toxicology; EPIDEMIOLOGIA; EPIDEMIOLOGIE; Furans - analysis; General aspects; GENERO HUMANO; GENRE HUMAIN; HERBICIDAS; HERBICIDE; HIDROCARBUROS HALOGENADOS; Humans; HYDROCARBURE HALOGENE; Male; Medical sciences; MEDICION; MESURE; Middle Aged; Polychlorinated Dibenzodioxins; Regression Analysis; TEJIDO ADIPOSO; TISSU ADIPEUX; Toxicology; VIET NAM; VIETNAM; Asia; Vietnam; Human; Evaluation; Adipose tissue; Rate; Exposure; Epidemiology; Statistical study; Chemical warfare agent; Pollutant; Environment; Vietnamese; Autochtonous; Public health
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1006/enrs.1994.1034

To permit new epidemiologic studies of the effects of dioxin on humans in Vietnam, we evaluated a model for quantifying exposure to Agent Orange (exposure index) based on the residential histories of 27 Vietnamese subjects and on information about spraying from the U.S. Army records (Herbs Tape) and compared this index to the dioxin levels measured in the subjects′ adipose tissue. The mean dioxin level was 7.8 ppt, and dioxin and furan isomer profiles were similar to those already reported in industrialized countries. In addition, there was a highly significant correlation between the levels of almost all the isomers, whatever their degree of chlorination. For the group of 27 subjects, we found a Pearson correlation coefficient of 0.36 (P = 0.07) between the dioxin levels and the exposure index after log-transformation of both variables. When the analysis was restricted to the 22 subjects with a positive exposure index, the Pearson correlation coefficient rose to 0.50 (P = 0.02). We conclude that despite the limitations and power conditions of the study, this result is encouraging because it will be useful for future epidemiologic studies in Vietnam.