Endothelium-Dependent Vasomotor Dysfunction in Pig Coronary Arteries With Paclitaxel-Eluting Stents Is Associated With Inflammation and Oxidative Stress

• Published in: JACC. Cardiovascular interventions Vol. 2; no. 3; pp. 253 - 262
• Main Authors: Pendyala, Lakshmana K., MD, Li, Jinsheng, MD, PhD, Shinke, Toshiro, MD, PhD, Geva, Sarah, PhD, Yin, Xinhua, MD, PhD, Chen, Jack P., MD, FACC, King, Spencer B., MD, MACC, Robinson, Keith A., PhD, FACC, Chronos, Nicolas A.F., MD, FACC, Hou, Dongming, MD, PhD, FACC
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2009
• Subjects: Animals; Antineoplastic Agents, Phytogenic - adverse effects; Cardiovascular; Coronary Artery Disease - drug therapy; Coronary Artery Disease - physiopathology; Coronary Vessels - injuries; Coronary Vessels - physiopathology; Disease Models, Animal; Drug-Eluting Stents; endothelial function; Endothelium, Vascular - injuries; Endothelium, Vascular - physiopathology; inflammation; Inflammation - chemically induced; Inflammation - etiology; Oxidative Stress; Paclitaxel - adverse effects; paclitaxel-eluting stent; Swine; NTG; NO; EDiR; relative light unit; drug-eluting stent(s); inflammation; nitroglycerin; RLU; substance P; endothelium-dependent relaxation; endothelial function; scanning electron microscopy; bare-metal stent(s); nitric oxide; NSRS; smooth muscle cell; paclitaxel-eluting stent; nonstented reference segment; prostaglandin; SMC; BMS; EDdR; ET; endothelin; DES; N-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid; HEPES; paclitaxel-eluting stent(s); PG; SEM; endothelium-independent relaxation; sP; oxidative stress; PES
• ISSN: 1936-8798; 1876-7605
• DOI: 10.1016/j.jcin.2008.11.009

Endothelium-Dependent Vasomotor Dysfunction in Pig Coronary Arteries With Paclitaxel-Eluting Stents Is Associated With Inflammation and Oxidative Stress Lakshmana K. Pendyala, Jinsheng Li, Toshiro Shinke, Sarah Geva, Xinhua Yin, Jack P. Chen, Spencer B. King III, Keith A. Robinson, Nicolas A. F. Chronos, Dongming Hou Even though paclitaxel-eluting stents (PES) were effective in reducing restenosis clinically, there are concerns about incomplete re-endothelialization, coronary artery spasm, and abnormal vasomotor function. To date, systematic investigation of vasoreactivity to endothelium-dependent vasodilators in vivo and in vitro following overlapping PES has not been reported. In this study, we demonstrated a profound impairment of endothelium-dependent endothelial function involving both coronary conduit and resistance arteries after overlapping PES implantation. Profound localized inflammatory reaction, as well as enhanced local oxidative stress, may contribute to vasomotor dysfunction.