Cyclosporin A protects against ischemia-reperfusion injury in the brain

We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex perfused by the middle cerebral artery (MCA...

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Bibliographic Details
Published inBrain research Vol. 595; no. 1; p. 145
Main Authors Shiga, Y, Onodera, H, Matsuo, Y, Kogure, K
Format Journal Article
LanguageEnglish
Published Netherlands 06.11.1992
Subjects
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Blood Urea Nitrogen
Brain Edema - pathology
Brain Injuries - pathology
Brain Injuries - prevention & control
Cerebral Arteries - physiology
Cyclosporine - pharmacology
Male
Rats
Rats, Wistar
Reperfusion Injury - pathology
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Summary:We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex perfused by the middle cerebral artery (MCA) and infarct size were decreased compared with those in olive oil treated control rats. These results suggest that CsA is beneficial in reducing ischemia-reperfusion injury, possibly by the suppression of immunological reactions.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(92)91465-q