The mouse as a model for developmental immunotoxicology

The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the pred...

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Published inHuman & experimental toxicology Vol. 21; no. 9-10; pp. 525 - 531
Main Authors Holladay, S D, Blaylock, B L
Format Journal Article Conference Proceeding
LanguageEnglish
Published Thousand Oaks, CA SAGE Publications 01.09.2002
Arnold
Sage Publications Ltd
Subjects
Age Factors
Animals
Antigens
Biological and medical sciences
Biological Assay
Disease Models, Animal
Embryonic and Fetal Development - drug effects
Embryonic and Fetal Development - immunology
Female
General aspects. Methods
Hazardous Substances - toxicity
Immune System - drug effects
Immune System - embryology
Immune System - growth & development
Laboratories
Lymphocytes
Medical sciences
Mice
Pregnancy
Prenatal Exposure Delayed Effects
Risk Assessment
Spleen
Thymus gland
Toxicity Tests - methods
Toxicity Tests - standards
Toxicology
Toxicology - methods
Toxicology - standards
United States
United States
Louisiana
United States > US
Virginia
mouse
risk assessment
model development
developmental immmunotoxicology
Immunopathology
Animal model
Vertebrata
Toxicology
Mammalia
Investigation method
Mouse
Rodentia
Development
Immune system
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Abstract The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the predictive strength of adult mouse immune screens for detecting either transient or long-lasting postnatal immune suppression. Limited information is also available regarding postnatal ages when various immune assays can be first employed to detect developmental immunotoxicity in mice. Furthermore, difficulties and expense inherent with breeding of in-bred mice, as used for adult immunotoxicity studies, raise questions regarding the feasibility of an in-bred mouse model as a standard, widely available developmental immunotoxicity testing system. These and additional concerns will need to be addressed as a model system with utility for studying developmental immunotoxicants is produced.
AbstractList The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the predictive strength of adult mouse immune screens for detecting either transient or long-lasting postnatal immune suppression. Limited information is also available regarding postnatal ages when various immune assays can be first employed to detect developmental immunotoxicity in mice. Furthermore, difficulties and expense inherent with breeding of in-bred mice, as used for adult immunotoxicity studies, raise questions regarding the feasibility of an in-bred mouse model as a standard, widely available developmental immunotoxicity testing system. These and additional concerns will need to be addressed as a model system with utility for studying developmental immunotoxicants is produced.
Author Holladay, S D
Blaylock, B L
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Issue 9-10
Keywords mouse
risk assessment
model development
developmental immmunotoxicology
Immunopathology
Animal model
Vertebrata
Toxicology
Mammalia
Investigation method
Mouse
Rodentia
Development
Immune system
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Snippet The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure....
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SubjectTerms Age Factors
Animals
Antigens
Biological and medical sciences
Biological Assay
Disease Models, Animal
Embryonic and Fetal Development - drug effects
Embryonic and Fetal Development - immunology
Female
General aspects. Methods
Hazardous Substances - toxicity
Immune System - drug effects
Immune System - embryology
Immune System - growth & development
Laboratories
Lymphocytes
Medical sciences
Mice
Pregnancy
Prenatal Exposure Delayed Effects
Risk Assessment
Spleen
Thymus gland
Toxicity Tests - methods
Toxicity Tests - standards
Toxicology
Toxicology - methods
Toxicology - standards
United States
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Title The mouse as a model for developmental immunotoxicology
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