The mouse as a model for developmental immunotoxicology

• Published in: Human & experimental toxicology Vol. 21; no. 9-10; pp. 525 - 531
• Main Authors: Holladay, S D, Blaylock, B L
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Thousand Oaks, CA SAGE Publications 01.09.2002; Arnold; Sage Publications Ltd
• Subjects: Age Factors; Animals; Antigens; Biological and medical sciences; Biological Assay; Disease Models, Animal; Embryonic and Fetal Development - drug effects; Embryonic and Fetal Development - immunology; Female; General aspects. Methods; Hazardous Substances - toxicity; Immune System - drug effects; Immune System - embryology; Immune System - growth & development; Laboratories; Lymphocytes; Medical sciences; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Spleen; Thymus gland; Toxicity Tests - methods; Toxicity Tests - standards; Toxicology; Toxicology - methods; Toxicology - standards; United States; United States; Louisiana; United States > US; Virginia; mouse; risk assessment; model development; developmental immmunotoxicology; Immunopathology; Animal model; Vertebrata; Toxicology; Mammalia; Investigation method; Mouse; Rodentia; Development; Immune system
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1191/0960327102ht292oa

The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the predictive strength of adult mouse immune screens for detecting either transient or long-lasting postnatal immune suppression. Limited information is also available regarding postnatal ages when various immune assays can be first employed to detect developmental immunotoxicity in mice. Furthermore, difficulties and expense inherent with breeding of in-bred mice, as used for adult immunotoxicity studies, raise questions regarding the feasibility of an in-bred mouse model as a standard, widely available developmental immunotoxicity testing system. These and additional concerns will need to be addressed as a model system with utility for studying developmental immunotoxicants is produced.