PDGFRβ Activation Induced the Bovine Embryonic Genome Activation via Enhanced NFYA Nuclear Localization

• Published in: International journal of molecular sciences Vol. 24; no. 23; p. 17047
• Main Authors: Perera, Chalani Dilshani, Idrees, Muhammad, Khan, Abdul Majid, Haider, Zaheer, Ullah, Safeer, Kang, Ji-Su, Lee, Seo-Hyun, Kang, Seon-Min, Kong, Il-Keun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023
• Subjects: activator; Animals; Becaplermin - metabolism; bovine blastocysts; Cattle; Cell cycle; Cell Differentiation; Cell division; DNA binding proteins; Embryonic development; embryonic genome activation; Embryos; Genes; Genetic transcription; Genomes; Genomics; Kinases; Localization; NFYA; PDGFRβ; Platelet-derived growth factor; Proteins; Receptor, Platelet-Derived Growth Factor alpha - genetics; Receptor, Platelet-Derived Growth Factor alpha - metabolism; Receptor, Platelet-Derived Growth Factor beta - genetics; Receptor, Platelet-Derived Growth Factor beta - metabolism; RNA; Signal Transduction - physiology; Transcription factors; PDGFRβ; activator; embryonic genome activation; NFYA; bovine blastocysts

Embryonic genome activation (EGA) is a critical step during embryonic development. Several transcription factors have been identified that play major roles in initiating EGA; however, this gradual and complex mechanism still needs to be explored. In this study, we investigated the role of nuclear tr...