Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia

• Published in: Metabolism, clinical and experimental Vol. 59; no. 7; pp. 1054 - 1056
• Main Authors: Stepan, Holger, Kralisch, Susan, Klostermann, Katrin, Schrey, Susanne, Reisenbüchler, Constanze, Verlohren, Michael, Verlohren, Hans-Joachim, Drynda, Kathrin, Blüher, Matthias, Stumvoll, Michael, Kratzsch, Jürgen, Kovacs, Peter, Fasshauer, Mathias
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2010; Elsevier
• Subjects: Adult; Biological and medical sciences; Blood Glucose - metabolism; Diabetes, Gestational - blood; Diseases of mother, fetus and pregnancy; Endocrinology & Metabolism; Enzyme-Linked Immunosorbent Assay; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gynecology. Andrology. Obstetrics; Humans; Insulin Resistance - physiology; Kidney Function Tests; Lipid Metabolism - physiology; Medical sciences; Pre-Eclampsia - blood; Pregnancy; Pregnancy. Fetus. Placenta; Serpins - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Adipokine; Gestational diabetes; Pregnancy disorders; Preeclampsia; Pregnancy toxemia; Endocrinology
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2009.11.001

Abstract The objective of the study was to investigate serum levels of the insulin-sensitizing adipokine vaspin in patients with gestational diabetes mellitus (GDM) and preeclampsia (PE) as compared with healthy controls of similar gestational age. Vaspin serum levels were quantified by enzyme-linked immunosorbent assay in control (n = 102), GDM (n = 40), and PE (n = 22) subjects. Median maternal vaspin concentrations were not significantly different in GDM, PE, and control subjects. Furthermore, vaspin did not significantly correlate to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Circulating vaspin levels are not significantly different between GDM, PE, and control subjects and do not correlate with insulin sensitivity in pregnant subjects.