Case report: accelerated cathodal HD-tDCS over the right dorsolateral prefrontal cortex in hoarding disorder

Hoarding disorder is an under-recognized condition characterized by the excessive acquisition of possessions and difficulty in disposing of them, which can have dramatic consequences. As hoarding disorder is difficult to treat and associated with high levels of disability in all areas of functioning...

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Published inFrontiers in human neuroscience Vol. 17; p. 1327811
Main Authors Brunelin, Jerome, Neige, Cécilia, Eche, Julien, Galvao, Filipe, Bation, Rémy, Mondino, Marine
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 11.03.2024
Frontiers
Frontiers Media S.A
Subjects
Anxiety
Brain
case report
Case reports
Clinical trials
Cognitive science
Comorbidity
depression
DLPFC
Electrodes
high-definition transcranial direct current stimulation
Hoarding behavior
Hoarding disorder
Human health and pathology
Impulsive behavior
Impulsivity
Intervention
Life Sciences
Mental depression
Mental disorders
Neuroscience
Obsessive compulsive disorder
Patients
Prefrontal cortex
Psychiatrics and mental health
Quality of life
Therapeutic applications
Transcranial magnetic stimulation
anxiety
case report
high-definition transcranial direct current stimulation
depression
DLPFC
hoarding disorder
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Summary:Hoarding disorder is an under-recognized condition characterized by the excessive acquisition of possessions and difficulty in disposing of them, which can have dramatic consequences. As hoarding disorder is difficult to treat and associated with high levels of disability in all areas of functioning, there appears to be a critical need to develop novel, tailored therapeutic strategies. Non-invasive brain stimulation techniques hold promise as potential therapeutic interventions for various psychiatric conditions and as a tool to modulate impulsivity when applied over the dorsolateral prefrontal cortex (DLPFC). Therefore, we hypothesized that delivering accelerated cathodal high-definition direct transcranial stimulation (HD-tDCS) over the right DLPFC could be a suitable approach to alleviate symptoms in patients with hoarding disorder. In a case report, we observed beneficial clinical effects on acquisition and depressive symptoms after 15 sessions of three daily 20-min sessions. Accelerated cathodal HD-tDCS over the right DLPFC appears to be a safe and appropriate intervention for patients with hoarding disorder. However, randomized, sham-controlled trials are needed to further validate these encouraging findings.
Bibliography:Georgios Mikellides, University of Nicosia, Cyprus
Reviewed by: Stevan Nikolin, University of New South Wales, Australia
Edited by: Elisa Kallioniemi, New Jersey Institute of Technology, United States
Sergei Tugin, Australian National University, Australia
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2023.1327811