Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions

Sarcopenia poses a significant challenge to public health and can severely impact the quality of life of aging populations. Despite extensive efforts to study muscle degeneration using traditional animal models, there is still a lack of effective diagnostic tools, precise biomarkers, and treatments...

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Published inInternational journal of molecular sciences Vol. 24; no. 23; p. 17018
Main Authors Callegari, Santiago, Mirzaei, Foad, Agbaria, Lila, Shariff, Sanobar, Kantawala, Burhan, Moronge, Desmond, Ogendi, Brian M O
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2023
Subjects
Adapter proteins
age-related muscle deficits
Aging
Atrophy
Biomarkers
Cryotherapy
Diagnosis
Disease
electrical impedance myography
Genetic engineering
Genomes
Medical research
Medicine, Experimental
Metabolism
Musculoskeletal system
Older people
Sarcopenia
Zebrafish
electrical impedance myography
aging
zebrafish
biomarkers
age-related muscle deficits
sarcopenia
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Summary:Sarcopenia poses a significant challenge to public health and can severely impact the quality of life of aging populations. Despite extensive efforts to study muscle degeneration using traditional animal models, there is still a lack of effective diagnostic tools, precise biomarkers, and treatments for sarcopenia. Zebrafish models have emerged as powerful tools in biomedical research, providing unique insights into age-related muscle disorders like sarcopenia. The advantages of using zebrafish models include their rapid growth outside of the embryo, optical transparency during early developmental stages, high reproductive potential, ease of husbandry, compact size, and genetic tractability. By deepening our understanding of the molecular processes underlying sarcopenia, we may develop novel diagnostic tools and effective treatments that can improve the lives of aging individuals affected by this condition. This review aims to explore the unique advantages of zebrafish as a model for sarcopenia research, highlight recent breakthroughs, outline potential avenues for future investigations, and emphasize the distinctive contributions that zebrafish models offer. Our research endeavors to contribute significantly to address the urgent need for practical solutions to reduce the impact of sarcopenia on aging populations, ultimately striving to enhance the quality of life for individuals affected by this condition.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242317018